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Journal of Cognitive Neuroscience

Monthly
208 pp. per issue   
8 1/2 x 11, illustrated
Founded: 1989
ISSN 0898-929X
E-ISSN 1530-8898
2013 Impact Factor: 4.687

Journal of Cognitive Neuroscience

Habitual versus Goal-directed Action Control in Parkinson Disease

Sanne de Wit1,2, Roger A. Barker2, Anthony D. Dickinson2, and Roshan Cools3

1University of Amsterdam, The Netherlands

2University of Cambridge, Cambridge, UK

3Radboud University Medical Centre, Nijmegen, The Netherlands

Full Text | PDF (215.081 KB) | PDF Plus (284.403 KB)

This study presents the first direct investigation of the hypothesis that dopamine depletion of the dorsal striatum in mild Parkinson disease leads to impaired stimulus–response habit formation, thereby rendering behavior slow and effortful. However, using an instrumental conflict task, we show that patients are able to rely on direct stimulus–response associations when a goal-directed strategy causes response conflict, suggesting that habit formation is not impaired. If anything our results suggest a disease severity–dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior.

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