Monthly 208 pp. per issue 8 1/2 x 11, illustrated Founded: 1989 ISSN 0898-929X E-ISSN 1530-8898 2013 Impact Factor: 4.687
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May 2011, Vol. 23, No. 5, Pages 1218-1229
Posted Online February 2, 2011.
(doi:10.1162/jocn.2010.21514)
© 2011 Massachusetts Institute of Technology
Habitual versus Goal-directed Action Control in Parkinson Disease Sanne de Wit1,2, Roger A. Barker2, Anthony D. Dickinson2, and Roshan Cools31University of Amsterdam, The Netherlands 2University of Cambridge, Cambridge, UK 3Radboud University Medical Centre, Nijmegen, The Netherlands
This study presents the first direct investigation of the hypothesis that dopamine depletion of the dorsal striatum in mild Parkinson disease leads to impaired stimulus–response habit formation, thereby rendering behavior slow and effortful. However, using an instrumental conflict task, we show that patients are able to rely on direct stimulus–response associations when a goal-directed strategy causes response conflict, suggesting that habit formation is not impaired. If anything our results suggest a disease severity–dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior. Cited byTheresa H. McKim, Charlotte A. Boettiger. 2015. Addiction as Maladaptive Learning, with a Focus on Habit Learning. The Wiley Handbook on the Cognitive Neuroscience of Addiction1-28. CrossRef Lorenz Deserno, Quentin J. M. Huys, Rebecca Boehme, Ralph Buchert, Hans-Jochen Heinze, Anthony A. 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